Multimodality Study for Restless Legs Syndrome Revealed Local Morphological Changes Associated with T2: Hypomyelination or Iron Deficiency?
نویسندگان
چکیده
Introduction: Restless leg syndrome (RLS) is a sensory-motor disorder characterized by uncontrollable urges to move the legs, causing chronic sleep disturbances. Brain iron deficiency has been considered as an important contributing factor to RLS [1-2]. In this study, we applied voxel-based relaxometry (VBR) for in vivo iron measurement and voxel-based morphometry (VBM) for morphological study respectively to a same study cohort, aiming to determine the impact of iron deficiency on brain morphology. Our results revealed a striking association of local T2 change with brain atrophy.
منابع مشابه
رابطه کمبود آهن و سندرم پاهای بیقرار در بیماران تحت همودیالیز
Introduction: Restless legs syndrome is a neurological disorder hemodialysis patients seem to suffer more from this syndrome. Although the pathophysiology of restless legs syndrome is still unknown, assessment of factors associated with this syndrome can help to develop medical knowledge in this field. The present study assessed the relationship between restless legs syndrome, serum iron, and s...
متن کاملReduction of R2 in the Basal Ganglia of Restless Legs Syndrome: a Biomarker for Iron Deficiency
Introduction: Restless legs syndrome (RLS) is a neurological disorder with a prevalence of about 5-10% of the general population. Its clinical symptom is characterized by uncontrollable, unbearable urges to move the legs, causing chronic sleep deprivation. The iron deficiency has been considered an important contributing factor for RLS [1]. In vivo iron evaluation for RLS has largely utilized T...
متن کاملMultimodality Study for Restless Legs Syndrome: Morphological Changes in White and Gray matter
Introduction: Restless leg syndrome (RLS) is a sensory-motor disorder causing chronic sleep disturbances. Currently, neuroradiological investigations such as functional MRI, voxel-based relaxometry (VBR) as well as nuclear medicine have revealed a widespread pattern of pathological changes involving cerebra, cerebella and brain stem [1-3]. Thus, underlying mechanism of RLS is not well-understoo...
متن کاملIncreased NAA Concentration in the Restless Legs Syndrome: Possible Link to Hypomyelination
Introduction: Iron deficiency has been known as a contributing factor for restless legs syndrome (RLS). Iron plays a pivotal role in brain physiology as an essential component for proper myelination, as a cofactor for enzymes in neurotransmitter synthesis, lipid and DNA synthesis. Most in vivo studies on RLS have been carried out with fMRI and MR relaxation mapping [1-3]. To date, the associate...
متن کاملSleep disorders: A review of the interface between restless legs syndrome and iron metabolism
Restless legs syndrome (RLS) is characterized by unpleasant sensations mainly in the legs. 43% of RLS-associated conditions have also been associated with systemic iron deficiency. The objective of this study was to review in the literature the relationship between iron metabolism and RLS. With an initial search using the keywords combination "Iron Metabolism OR Iron Deficiency AND Restless Leg...
متن کامل